Hydrochloric Acid → HCID 70906909, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-benzyl 8,8-dimethyl-6,10-dioxaspiro[4.5]decane-2-carboxylate (3.5 g, 11.50 mmol) in ethanol (50 ml) at 0° C. was added 0.1 N hydrochloric acid (17.5 ml) drop wise. The reaction was stirred at 25° C. for overnight. Upon completion, the reaction mixture was concentrated under reduced pressure; the residue was dissolved in dichloromethane (50 ml) and diluted with water (25 ml). The organic mass was extracted using dichloromethane (2×50 ml) and the combined organic layer was dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography over silica gel using ethyl acetate in hexane as eluents to obtain (S)-benzyl 3-oxocyclopentanecarboxylate (2 g, 80%).

Provenance & Evidence