HCID 136951802, compound → HCID 136493144, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (R)-2′-(3-(4-(2-fluoro-4-iodophenyl)piperazin-1-yl)cyclopent-1-en-1-yl)-7′,8′-dihydro-3′H-spiro[cyclopropane-1,6′-quinazolin]-4′(5′H)-one (synthesis from (R)-3-aminocyclopent-1-enecarbonitrile and 2-fluoro-4-iodoaniline as described in example 11) (0.160 g, 0.293 mmol) in N,N-dimethylformamide (10 ml) was added dicyanozinc (0.344 g, 2.93 mmol) at 25° C. The reaction mixture was heated to 115-120° C. for 4 h. Progress of the reaction was monitored by TLC. After completion of reaction, reaction mixture was cooled and solvent was evaporated under reduced pressure to obtain crude product. Crude product was purified by flash column chromatography over silica gel (110-200 mesh) using 6% methanol in in dichloromethane as eluent to obtain title compound (0.045 g, 34.5%).

Provenance & Evidence