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N'-Hydroxycyclopropanecarboximidamide → {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(1,1-difluoroethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N'-Hydroxycyclopropanecarboximidamide | HCID 2794666 | — |
| 反応物 | 5-[4-(1,1-Difluoroethyl)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58116549 | — |
| 生成物 | {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(1,1-difluoroethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone | HCID 59606568 | — |
反応手順
According to General Method 6A, 150 mg (0.376 mmol) of the compound from Example 53A and 41.5 mg (0.414 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted Yield: 77.9 mg (44% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202862B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-911ab3139d7d46edb20f9624234d63dc |
| 出典メモ | uspto-grants-2012_06 |