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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 220045Generated: October 29, 2026

2-(4-Bromophenyl)ethanol → Methyl 5-[4-(2-hydroxyethyl)phenyl]nicotinate

https://huagongshe.com/reaction/220045

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Bromophenyl)ethanolHCID 72851—
Reactant3-(Methoxycarbonyl)pyridine-5-boronic acid, pinacol esterHCID 17750257—
ProductMethyl 5-[4-(2-hydroxyethyl)phenyl]nicotinateHCID 59606586—

Reaction Steps

According to General Method 3A, 6.00 g (29.8 mmol) of 2-(4-bromophenyl)ethanol and 19.6 g (74.6 mmol) of methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate were reacted. Yield: 6.12 g (74% of theory)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08202862B2
Source datasetuspto-grants-2012_06
ORD IDord-6a4e13e1c5c44175bfa4e62686f61a05
Source noteuspto-grants-2012_06