HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → Thieno[3,2-c]isothiazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | 3-Amino-2-thiophenecarbothioamide | HCID 14321102 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Thieno[3,2-c]isothiazol-3-amine | HCID 818861 | — |
Reaction Steps
To a solution of crude 3-aminothiophene-2-carbothioamide in MeOH (5 mL) was added H2O2 (30%, 0.6 mL), after stirring at room temperature for 15 min, it was concentrated to remove most of MeOH, and then diluted with EtOAC, organic layer was washed with brine, concentrated to give crude pdt, purification by column chromatography (DCM/EtOAC=3:1) gave thieno[3,2-c]isothiazol-3-amine (334 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359308B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-282819540fdd48a7af87715042a2a4f2 |
| Source note | uspto-grants-2016_06 |