HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 220052Generated: October 29, 2026
Thiomorpholine → {3-[4-(2,2-Difluoroethyl)phenyl]-5-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}(thiomorpholin-4-yl)methanone
https://huagongshe.com/reaction/220052
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Nitrophenyl 3-[4-(2,2-difluoroethyl)phenyl]-5-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate | HCID 59606576 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | {3-[4-(2,2-Difluoroethyl)phenyl]-5-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}(thiomorpholin-4-yl)methanone | HCID 59606564 | — |
Reaction Steps
A solution of 56.0 mg (0.065 mmol, purity 60%) of the compound from Example 62A in 1-methyl-2-pyrrolidone (2.0 ml) was admixed with 37.0 μl (40.0 mg, 0.390 mmol) of thiomorpholine and 34.0 μl (25.0 mg, 0.195 mmol) of N,N-diisopropylethylamine and then heated in a single-mode microwave (Emrys Optimizer) at 150° C. for 30 min. For workup, the reaction solutions were combined and purified directly by means of preparative HPLC. Yield: 14.7 mg (47% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08202862B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-a89d5348868a4001b44b94d681aac90d |
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| Source note | uspto-grants-2012_06 |
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