Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Dithionite | HCID 24489 | — |
| Reactant | 6-Amino-3-methyl-5-nitroso-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 3247720 | — |
| Solvent | Ammonium Hydroxide | HCID 14923 | — |
| Product | SS-3364 | HCID 1201412 | 30.1% |
Reaction Steps
To a solution of 6-amino-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione in ammonium hydroxide (100 mL) was added sodium hydrosulfite (6.8 g, 39.1 mmol) in small portions at 70° C., the mixture was stirred at 70° C. for 1 h. The mixture was concentrated and ice-water was added. The slurry was filtered and the filter cake was washed with water and ethanol and dried under vacuum to give 5,6-diamino-3-methylpyrimidine-2,4(1H,3H)-dione (2.0 g, 30.1% yield over two steps) as yellow solid. LCMS MH+ 157.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09359359B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-1ab726b5306d4b009486b00b20057be0 |
|---|
| Source note | uspto-grants-2016_06 |
|---|
