HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-METHYLACETOPHENONE → 1-[4-(Bromomethyl)phenyl]ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-METHYLACETOPHENONE | HCID 8500 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 1-[4-(Bromomethyl)phenyl]ethan-1-one | HCID 583785 | 71.7% |
Reaction Steps
To a solution of 1-p-tolylethanone (600 mg, 4.47 mmol) in carbon tetrachloride (15 mL) was added N-bromosuccinimide (955 mg, 5.37 mmol) and BPO (31 mg, 0.13 mmol). The mixture was refluxed for 3 h; then it was cooled, and filtered. The filtrate was concentrated to give 1-(4-(bromomethyl)phenyl)ethanone (683 mg, 71%) as a brown oil. LCMS MH+ 213.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359359B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-f7e05d3384964ecda9f2682b8cc6c3cd |
| Source note | uspto-grants-2016_06 |