反应详情

To a solution of 2-methylpyrimidine-5-carboxylic acid (150 mg, 1.23 mm01) in ethanol (5 mL) was added sodium borohydride (93 mg, 2.46 mmol). The mixture was stirred at room temperature for 3 h. It was quenched with aqueous HCl (2 N, 2 mL), extracted with DCM, dried over sodium sulfate, filtered and concentrated give the yellow oil product (2-methylpyrimidin-5-yl)methanol (95 mg, 62.6%). LCMS MH+ 125.

1. customIt was quenched with aqueous HCl (2 N, 2 mL)
2. extractionextracted with DCM
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated