Methanesulfonyl chloride → HCID 90403073, compound

HRID 2200585Notes

Reaction equation

HRID 2200585 reaction equation
[C:1]1([CH2:6][OH:7])([CH2:4][OH:5])[CH2:3][CH2:2]1.[CH3:8][S:9](Cl)(=[O:11])=[O:10]>C(Cl)Cl>[CH3:8][S:9]([O:5][CH2:4][C:1]1([CH2:6][OH:7])[CH2:3][CH2:2]1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 41014371,1-Bis(hydroxymethyl)cyclopropane

Product 1

HCID 90403073HCID 90403073, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of cyclopropane-1,1-diyldimethanol (0.1 g, 0.98 mmol) in DCM (5 mL) was added TEA (0.15 g, 1.44 mmol). Methanesulfonyl chloride (0.11 g, 0.98 mmol) was added dropwise at 0° C. The reaction was stirred at room temperature for 2 h. The mixture was partitioned between DCM and water. The combined organic layer was dried over sodium sulfate, filtered and concentrated to give a crude product which was used without purification.

Workup

  1. customThe mixture was partitioned between DCM and water
  2. dry with materialThe combined organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-0253d89d52324ac1a93c275cc093459a
Source dataset
uspto-grants-2016_06
Patent number
US09359359B2

Reaction notes

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