HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(Chloromethyl)-5-methylpyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (5-Methylpyridin-2-yl)methanol | HCID 12325387 | — |
| Product | 2-(Chloromethyl)-5-methylpyridine hydrochloride | HCID 23313795 | 91.3% |
Reaction Steps
A solution of (5-methylpyridin-2-yl)methanol in SOCl2(10 mL) was refluxed 30 min. The mixture was concentrated and dried in vacuo to give 2-(chloromethyl)-5-methylpyridine hydrochloride (2.1 g, 91.3% yield) as white solid. LCMS MH+ 142.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359359B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-c13b11f1820c4f44826724b9b69c605d |
| Source note | uspto-grants-2016_06 |