反应详情

温度

90 °C

In a reactor carousel test tube which had been dried by heating and preheated to 100° C., the degassed diluent mixture dioxane (20 ml)/water (7 ml) was added to 6-chloro-N-cyclopropylpyrimidine-4,5-diamine (10 g, 54.1 mmol) and sodium carbonate (17.22 g, 162 mmol). 5 mol % of tetrakis(triphenylphosphine)palladium(0) and 4-chlorophenylboronic acid (108.2 mmol) were added, and the reaction mixture was stirred at 90° C. overnight. The solution was cooled, filtered and concentrated and the residue was recrystallised from acetonitrile.

1. customIn a reactor carousel test tube which had been dried
2. temperatureby heating
3. custompreheated to 100° C.
4. temperatureThe solution was cooled
5. filtrationfiltered
6. concentrationconcentrated
7. customthe residue was recrystallised from acetonitrile