HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2200691Generated: November 1, 2026
Sodium methanethiolate → 7-(4-chlorobenzyl)-3-methyl-8-(methylthio)-1-(3-(tetrahydro-2H-pyran-2-yloxy)propyl)-1H-purine-2,6(3H,7H)-dione
https://huagongshe.com/reaction/2200691
Participants
| Role | Name | HCID | Charge |
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| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | 8-bromo-7-(4-chlorobenzyl)-3-methyl-1-(3-(tetrahydro-2H-pyran-2-yloxy)propyl)-1H-purine-2,6(3H,7H)-dione | HCID 90402682 | — |
| Product | 7-(4-chlorobenzyl)-3-methyl-8-(methylthio)-1-(3-(tetrahydro-2H-pyran-2-yloxy)propyl)-1H-purine-2,6(3H,7H)-dione | HCID 90402718 | — |
Reaction Steps
8-bromo-7-(4-chlorobenzyl)-3-methyl-1-(3-(tetrahydro-2H-pyran-2-yloxy)propyl)-1H-purine-2,6(3H,7H)-dione (0.15 g, 0.35 mmol, intermediate 14) was dissolved in sodium thiomethoxide (5 mL). The reaction was heated at 80° C. overnight. The mixture was cooled and partitioned between ethyl acetate and water. The combined organic layer was dried over sodium sulfate, filtered and concentrated to give a crude product which was used without purification. LCMS retention time 1.875 min; LCMS MH+-THP 395.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09359359B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-da2b16b36ae24f7fa6d947b6053cc5f9 |
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| Source note | uspto-grants-2016_06 |
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