Morpholine → (3R,6R)-3-(2,3-Dihydro-1H-inden-2-yl)-1-((1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl)-6-((1S)-1-methylpropyl)-2,5-piperazinedione

HRID 220074Notes

Reaction equation

HRID 220074 reaction equation
Cl.[CH2:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]1[C@H:11]1[NH:16][C:15](=[O:17])[C@@H:14]([C@@H:18]([CH3:21])[CH2:19][CH3:20])[N:13]([CH:22]([C:26]2[C:27]([CH3:33])=[N:28][C:29]([CH3:32])=[CH:30][CH:31]=2)[C:23](O)=[O:24])[C:12]1=[O:34].[NH:35]1[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1>ClCCl>[CH2:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]1[C@H:11]1[NH:16][C:15](=[O:17])[C@@H:14]([C@@H:18]([CH3:21])[CH2:19][CH3:20])[N:13]([C@H:22]([C:26]2[C:27]([CH3:33])=[N:28][C:29]([CH3:32])=[CH:30][CH:31]=2)[C:23]([N:35]2[CH2:40][CH2:39][O:38][CH2:37][CH2:36]2)=[O:24])[C:12]1=[O:34]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 56949593{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}(2,6-dimethyl-3-pyridinyl)acetic acid hydrochloride2×

Product 1

HCID 11634973(3R,6R)-3-(2,3-Dihydro-1H-inden-2-yl)-1-((1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl)-6-((1S)-1-methylpropyl)-2,5-piperazinedioneYield 45%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A suspension of {(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}(2,6-dimethyl-3-pyridinyl)acetic acid hydrochloride (5.0 g, 10.3 mmol) (intermediate 5) in dry dichloromethane (50 ml) was treated with 1,1-carbonyldiimidazole (2.6 g, 16 mmol) and the reaction mixture was stirred under nitrogen for 18 hours. Morpholine (4.8 ml, 55 mmol) was added and the resultant solution was left to stand under nitrogen for 18 hours. The solvent was removed in vacuo and the residue was separated between ethyl acetate and water. The organic phase was washed with brine and dried over anhydrous magnesium sulphate. The solvent was removed in vacuo and the residue was dissolved in dichloromethane. This was applied to a basic alumina cartridge (240 g) and eluted using a gradient of 0-7.5% methanol in diethyl ether (9CV), 7.5-10% methanol in diethyl ether (1CV) and 10% methanol in diethyl ether (1CV). The required fractions were combined and evaporated in vacuo to give (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione as a white solid (2.4 g, 45%).

Workup

  1. waitto stand under nitrogen for 18 hours
  2. customThe solvent was removed in vacuo
  3. customthe residue was separated between ethyl acetate and water
  4. washThe organic phase was washed with brine
  5. dry with materialdried over anhydrous magnesium sulphate
  6. customThe solvent was removed in vacuo
  7. dissolutionthe residue was dissolved in dichloromethane
  8. washeluted
  9. customevaporated in vacuo

Sources & evidence

ORD record
ord-cfb24372c400428a94c3c60083daf763
Source dataset
uspto-grants-2012_06
Patent number
US08202864B2

Reaction notes

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