Ethyl Acetate → HCID 178504217, compound

Participants

Reaction Conditions

Reaction Steps

{1-(cis-4-{[6-(Hydroxymethyl)-2-(trifluoromethyl)pyrimidin-4-yl]oxy}cyclohexyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile (110.0 mg, 0.1609 mmol) was dissolved in methylene chloride (2.22 mL) and was cooled to 0° C. To that was added N,N-diisopropylethylamine (45.8 μL, 0.263 mmol), followed by methanesulfonyl chloride (18 μL, 0.23 mmol). The reaction was stirred at 0° C. for 1 hour. The reaction was worked up using EtOAc and used in the next reaction. MS (ES): 762 (M+1).

Provenance & Evidence