HCID 90001511, compound → HCID 89996657, compound

Participants

Reaction Steps

To a solution of benzyl 2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethyl-[2-(2-hydroxyethoxyl)ethyl]amino]acetate (19) (1.25 g, 2.84 mmol) in DCM (4 mL) and methanol (6 mL) was added palladium (10%) on activated carbon (100 mg). The resulting mixture was placed under an atmosphere of hydrogen. The mixture was stirred at room temperature overnight and then filtered through Celite. The Celite was washed with methanol (2×20 mL) and the combined filtrates were concentrated at reduced pressure to give 1.20 g of 20. 13C NMR (CD3OD, 125 MHz) δ 170.5, 156.2, 79.3, 72.8, 70.6, 66.8, 61.4, 55.2, 55.0, 40.3, 28.5. ESMS (C15H31N2O7) [M+H]+ calc. 351.2131. found 351.2127.

Provenance & Evidence