3-Pyridinecarboxylic acid, 4-(acetylamino)phenyl ester → HCID 86717653, compound

Participants

Reaction Steps

To a solution of 4-acetamidophenyl nicotinate [297], (0.05 g, 1.95 mmol, 1.0 eq) in acetonitrile (4 ml) was added iodomethyl diisopropylcarbamate [6304] (0.055 g, 1.95 mmol, 1.0 eq). The resulting reaction mixture was stirred overnight at RT. The reaction was monitored by TLC. Acetonitrile was removed under vacuum and the resulting crude mixture was washed with diethyl ether (10 ml) to give pale yellow solid product 3-((4-acetamidophenoxy)carbonyl)-1-(((diisopropylcarbamoyl)oxy)methyl)pyridin-1-ium iodide [298] (0.086 g, 81%).

Provenance & Evidence