HCID 86715162, compound → HCID 86717658, compound

Participants

Reaction Steps

Iodomethyl isopropylcarbamate [6318] (0.018 g, 0.028 mmol, 1.0 eq) was added to a solution of (3-(4-amino-1-oxoisoindolin-2-yl)-2,6-dioxopiperidin-1-yl)methyl nicotinate [339] (0.03 g, 0.028 mmol, 1.0 eq) in DCM (5 ml). The reaction mixture was stirred at RT for 16 h. The DCM was evaporated under reduced pressure and washed thoroughly with diethyl ether to yield a yellow powder [340], 3-(((3-(4-amino-1-oxoisoindolin-2-yl)-2,6-dioxopiperidin-1-yl)methoxy)carbonyl)-1-(((isopropylcarbamoyl)oxy)methyl)pyridin-1-ium iodide, (0.015 g, 40%).

Provenance & Evidence