Imatinib → HCID 73669484, compound

Participants

Reaction Steps

Imatinib [148] (0.100 g, 0.2 mmol, 1 eq) was dissolved in DCM (10 ml) in a 25 ml two-necked round bottomed flask and iodomethyl pivalate [40] (0.185 g, 0.77 mmol, 3.8 eq) was added while stirring at RT. After 48 h stirring, the precipitate formed was filtered under vacuum and washed with DCM to give the product, 1-methyl-4-(4-((4-methyl-3-((4-(1-((pivaloyloxy)methyl)pyridin-1-ium-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)-1-((pivaloyloxy)methyl)piperazin-1-ium diiodide [42], as a yellow solid. (0.050 g, 25% yield).

Provenance & Evidence