Dichloromethane → HCID 89589801, compound

Participants

Reaction Steps

In DCM (10 mL) was dissolved tert-butyl 4-((6-chloro-3-((methylamino)methyl)-1,5-naphthyridin-4-yl)amino)piperidine-1-carboxylate (0.312 g, 0.77 mmol). The solution was cooled in an ice bath, and triphosgene (0.274 g, 0.923 mmol) and triethylamine (0.324 mL) were added. Then the reaction mixture was stirred at ambient temperature for 2 h. The reaction was quenched with saturated aqueous sodium carbonate and extracted with DCM. The organic phase was dried over sodium sulfate. The solvent was removed under reduced pressure to give a solid (0.332 g), which was used in the subsequent procedure without further purification.

Provenance & Evidence