反应详情

In absolute anhydrous THF (30 mL) were dissolved 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylsulfinyl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-formamide (222 mg, 0.5 mmol) and triethylamine (0.25 mL, 1.35 mmol). 3-oxo-8-azabicyclo[3.2.1]octane hydrochloride salt (90 mg, 0.6 mmol) was then added. The reaction was conducted at ambient temperature overnight. The solvent was removed by rotary evaporation, followed by addition of water and extraction with DCM. The organic phase was dried over sodium sulfate and purified by silica gel column chromatography (petroleum ether/ethyl acetate=1/1) to give a white solid (60 mg, 24% yield).

1. customThe solvent was removed by rotary evaporation
2. additionfollowed by addition of water and extraction with DCM
3. dry with materialThe organic phase was dried over sodium sulfate
4. custompurified by silica gel column chromatography (petroleum ether/ethyl acetate=1/1)