(Methoxycarbonylsulfamoyl)triethylammonium hydroxide → HCID 66628342, compound

Participants

Reaction Steps

The reaction was carried out under argon. (7R)-7-(4-Cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide (34 mg, 80 μmol) was initially charged in dry THF (1.9 ml), methoxycarbonylsulfamoyltriethylammonium hydroxide (Burgess reagent; 76 mg, 320 μmol, 4 eq.) was added and the mixture was stirred at RT for 1 h. HPLC showed complete conversion. The reaction mixture was then concentrated and the residue was purified by preparative HPLC (Gromsil C18 column, 10 μm; mobile phase: acetonitrile/water+0.1% TFA 10:90→90:10). The title compound was obtained as a solid (29 mg, 89% of theory).

Provenance & Evidence