HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Bromo-4-fluorobenzonitrile | HCID 118939 | — |
| Reactant | (2R)-2-amino-3-phenylpropanamide | HCID 7000171 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide | HCID 67509091 | 23.3% |
Reaction Steps
A solution of 2-bromo-4-fluorobenzonitrile (255 mg, 1.27 mmol), D-phenylalanine amide (220 mg, 1.34 mmol) and DIEA (0.466 mL, 2.68 mmol) in DMSO (3 mL) was stirred at 100 C for 18 h. The mixture was then purified by HPLC to give (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide (102 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359375B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-f810a0b00e54457e930346cc400085d7 |
| Source note | uspto-grants-2016_06 |