HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 1-amino-4,4,4-trifluoro-1-oxobutan-2-ylcarbamate → 2-Amino-4,4,4-trifluorobutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 1-amino-4,4,4-trifluoro-1-oxobutan-2-ylcarbamate | HCID 67515558 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-4,4,4-trifluorobutanamide | HCID 44717372 | 93.5% |
Reaction Steps
A solution of benzyl 1-amino-4,4,4-trifluoro-1-oxobutan-2-ylcarbamate (175 mg, 0.603 mmol) and Pd—C (10%, 55 mg) in MeOH (5 mL) was hydrogenated under balloon hydrogen for 2 h. The mixture was filtered through celite. The filtrate was concentrated in vacuo to give 2-amino-4,4,4-trifluorobutanamide (88 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359375B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-d9a282c4ce7e4173a232a8f9646d384f |
| Source note | uspto-grants-2016_06 |