HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2201145Generated: October 29, 2026
Diisopropylethylamine → (R)-benzyl 1-(1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)propyl)cyclopropylcarbamate
https://huagongshe.com/reaction/2201145
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,6-Dichloro-5-fluoronicotinamide | HCID 2774022 | — |
| Reactant | (R)-benzyl-1-(1-aminopropyl)cyclopropylcarbamate hydrochloride | HCID 86666166 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | (R)-benzyl 1-(1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)propyl)cyclopropylcarbamate | HCID 86666165 | 44.8% |
Reaction Steps
To a solution of 2,6-dichloro-5-fluoronicotinamide (233 mg, 1.22 mmol) in NMP (5.0 mL) was added (R)-benzyl-1-(1-aminopropyl)cyclopropylcarbamate hydrochloride salt (350 mg, 1.23 mmol) and DIPEA (0.434 mL, 2.44 mmol). After heated at 80° C. for 4 h, the mixture was diluted with EtOAc, organic layer was washed brine, dried and concentrated to give (R)-benzyl 1-(1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)propyl)cyclopropylcarbamate (220 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09359375B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-6af93425e4d44c41a5c8b90596cb676d |
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| Source note | uspto-grants-2016_06 |
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