HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Amino-4,4,4-trifluorobutanamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 1-amino-4,4,4-trifluoro-1-oxobutan-2-ylcarbamate | HCID 86666168 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Amino-4,4,4-trifluorobutanamide hydrochloride | HCID 86666169 | — |
Reaction Steps
A solution of the solid tert-butyl 1-amino-4,4,4-trifluoro-1-oxobutan-2-ylcarbamate in dioxane (4 mL) and aq. 6N HCl (6 mL) was stirred at room temperature for 1 h. It was then concentrated in vacuo to give 2-amino-4,4,4-trifluorobutanamide hydrochloride as a solid (135 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359375B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-5b779918e3e840c3b0b0ab3f9e3437e0 |
| Source note | uspto-grants-2016_06 |