Pyridinium chloride → HCID 86723475, compound

Participants

Reaction Steps

Pyridine hydrochloride (6.02 g, 52.1 mmol) was added to a suspension of 6-(4-(4-chlorothiazol-2-yl)-4-oxobutyl)-1,3-dimethyl-5-(1-methyl-1H-pyrazol-3-yl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (2.33 g, 5.21 mmol) in methanol (82 ml) and water (8.17 ml) and the mixture stirred at room temperature for 3 days. The mixture was then diluted with chloroform (300 ml), washed with 1M HCl(aq) (3×100 ml) and saturated NaHCO3(aq) (100 ml). The organic phase was passed through a hydrophobic frit and evaporated under vacuum. Purification by chromatography on silica, eluting with 50-80% EtOAc/hexane afforded a crude material which was triturated with methanol to afford the title compound.

Provenance & Evidence