Sodium Hydroxide → Sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate

HRID 2201244Notes

Reaction equation

HRID 2201244 reaction equation
[OH-:1].[Na+:2].[F:3][C:4]1[CH:5]=[C:6]([C:10]2[N:11]([CH2:23][CH:24]3[CH2:28][C:27](=[O:29])[O:26][CH2:25]3)[CH:12]=[C:13]3[C:18]=2[C:17](=[O:19])[N:16]([CH3:20])[C:15](=[O:21])[N:14]3[CH3:22])[CH:7]=[CH:8][CH:9]=1>C(O)C>[F:3][C:4]1[CH:5]=[C:6]([C:10]2[N:11]([CH2:23][CH:24]([CH2:25][OH:1])[CH2:28][C:27]([O-:26])=[O:29])[CH:12]=[C:13]3[C:18]=2[C:17](=[O:19])[N:16]([CH3:20])[C:15](=[O:21])[N:14]3[CH3:22])[CH:7]=[CH:8][CH:9]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 867234785-(3-fluorophenyl)-1,3-dimethyl-6-((5-oxotetrahydrofuran-3-yl)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Product 1

HCID 86723479Sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium hydroxide (2M, 2.00 mL, 4.0 mmol) was added to a suspension of 5-(3-fluorophenyl)-1,3-dimethyl-6-((5-oxotetrahydrofuran-3-yl)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1.35 g, 3.6 mmol) in ethanol (27 mL). The mixture was stirred at room temperature for 2 hours. The solvents were evaporated under vacuum to afford the title compound.

Workup

  1. customThe solvents were evaporated under vacuum

Sources & evidence

ORD record
ord-305d531b04a142beb6a5e80b0f496776
Source dataset
uspto-grants-2016_06
Patent number
US09359381B2

Reaction notes

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