HCID 86723486, compound → HCID 86723487, compound

Participants

Reaction Conditions

Reaction Steps

(S)-2-(1,3-Dimethyl-2,4-dioxo-5-phenyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)pentanedioic acid (2.44 g, 6.33 mmol) and polyphosphoric acid (4.85 ml, 6.33 mmol) were combined and heated at 110° C. for 85 mins. The reaction mixture was cooled to ˜50° C. and diluted with water to give a fluid mixture. The mixture was then cooled to room temperature, further diluted with water and extracted with chloroform (5×). The combined organic extracts were passed through a hydrophobic frit and evaporated under vacuum to afford the title compound.

Provenance & Evidence