2-Methylfuran → HCID 86723490, compound

Participants

Reaction Steps

Gold (III) chloride (0.142 g, 0.469 mmol) was added to a solution of (7S)-methyl 10-hydroxy-1,3-dimethyl-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate (1.8 g, 4.69 mmol) and 2-methylfuran (0.466 mL, 5.16 mmol) in acetonitrile (30 mL). The mixture was stirred at room temperature for 25 mins, then quenched with saturated NaHCO3(aq). The mixture was extracted with DCM, the organic phase passed through a hydrophobic frit and evaporated under vacuum.

Provenance & Evidence