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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2201268Generated: October 29, 2026

Ethyl 5-bromovalerate → Ethyl 5-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)pentanoate

https://huagongshe.com/reaction/2201268

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 5-bromovalerateHCID 84580—
Reactant3-(1,3-Dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrileHCID 86722928—
ProductEthyl 5-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)pentanoateHCID 86723508—

Reaction Steps

The title compound was prepared from 3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile (Example 9, step 4) and ethyl 5-bromopentanoate (0.712 mL, 4.50 mmol) by an analogous method to Example 9 step 5;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09359381B2
Source datasetuspto-grants-2016_06
ORD IDord-5faf624ea5fd4a98b6646abaf9b25505
Source noteuspto-grants-2016_06