1-Pyrrolidinepropanamine → HCID 42599154, compound

HRID 220129Notes

Reaction equation

HRID 220129 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH2:9][C:10]([NH2:12])=[O:11])[C:5]([C:13]#[N:14])=[C:4]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[C:3]=1[C:20]#[N:21].[N:22]1([CH2:27][CH2:28][CH2:29]N)[CH2:26][CH2:25][CH2:24][CH2:23]1>>[NH2:14][C:13]1[C:5]2[C:6](=[N:7][C:2]([NH:1][CH2:29][CH2:28][CH2:27][N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[C:3]([C:20]#[N:21])[C:4]=2[C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[S:8][C:9]=1[C:10]([NH2:12])=[O:11]

Participants

3

Reactant 2

HCID 316701-PyrrolidinepropanamineHCID 1899510HCID 1899510, compound

Product 1

HCID 42599154HCID 42599154, compound

Procedure

If steps 1.1 and 1.2 according to Example 1 are carried out analogously with furan-2-carbaldehyde as “E1”, 2-(6-amino-4-furan-2-yl-3,5-dicyanopyridin-2-ylsulfanyl)acetamide (“2a”) is obtained. “2a” is subsequently reacted analogously to steps 2.1 to 2.3 according to Example 2, using 3-pyrrolidin-1-ylpropylamine as “E2” in step 2.2. 3-Amino-5-cyano-4-furan-2-yl-6-(3-pyrrolidin-1-ylpropylamino)thieno[2,3-b]pyridine-2-carboxamide “A51” is obtained.

Sources & evidence

ORD record
ord-f1e910ac66f746159b97a5bf107da643
Source dataset
uspto-grants-2012_06
Patent number
US08202882B2

Reaction notes

Loading…