Trifluoroacetic acid → HCID 86723529, compound

Participants

Reaction Steps

1,3-Diethyl-5-phenyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (step 4) (1.45 g, 2.475 mmol) was dissolved in DCM (50 mL) and treated with TFA (5 mL, 64.9 mmol) followed by triethylsilane (0.791 mL, 4.95 mmol). The mixture was stirred at RT for 16 h. The reaction mixture was basified by slow addition of sat. NaHCO3(aq) and extracted with DCM. The organic phase was passed through a hydrophobic frit and evaporated under vacuum. The residue was dissolved in DCM, evaporated onto silica and the silica deposited onto a 10 g silica cartridge. The system was eluted with 20%-60% EtOA in iso-hexane to yield the title compound as a pale yellow oil.

Provenance & Evidence