1H-Imidazole-1-propanamine → HCID 59486159, compound

HRID 220130Notes

Reaction equation

HRID 220130 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH2:9][C:10]([NH2:12])=[O:11])[C:5]([C:13]#[N:14])=[C:4]([C:15]2[O:16][C:17]([CH3:20])=[CH:18][CH:19]=2)[C:3]=1[C:21]#[N:22].[N:23]1([CH2:28][CH2:29][CH2:30]N)[CH:27]=[CH:26][N:25]=[CH:24]1>>[NH2:14][C:13]1[C:5]2[C:6](=[N:7][C:2]([NH:1][CH2:30][CH2:29][CH2:28][N:23]3[CH:27]=[CH:26][N:25]=[CH:24]3)=[C:3]([C:21]#[N:22])[C:4]=2[C:15]2[O:16][C:17]([CH3:20])=[CH:18][CH:19]=2)[S:8][C:9]=1[C:10]([NH2:12])=[O:11]

Participants

3

Reactant 2

HCID 787361H-Imidazole-1-propanamineHCID 68505308HCID 68505308, compound

Product 1

HCID 59486159HCID 59486159, compound

Procedure

“2c” is subsequently reacted analogously to steps 2.1 to 2.3 according to Example 2, using 3-imidazol-1-ylpropylamine as “E2” in step 2.2. 3-Amino-5-cyano-6-(3-imidazol-1-ylpropylamino)-4-(5-methylfuran-2-yl)thieno[2,3-b]-pyridine-2-carboxamide “A59” is obtained.

Sources & evidence

ORD record
ord-3864f35529d2416893ccb37cd4dfee80
Source dataset
uspto-grants-2012_06
Patent number
US08202882B2

Reaction notes

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