Water → HCID 86723537, compound

Participants

Reaction Steps

Lithium hydroxide (2.64 g, 63.0 mmol) was added to a solution of ethyl 4-(1,3-dimethyl-2,4-dioxo-5-m-tolyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoate (step 1) (4.83 g, 12.6 mmol) in THF (48 mL)/water (12 mL). The mixture was stirred at room temperature for 24 hours. The organic solvent was largely removed under vacuum, the residue was acidified to pH 1, using 1M. The precipitate was extracted into chloroform (1×100 mL, 4×50 mL). The combined organic extracts were dried with magnesium sulfate and the solvent was removed under vacuum. The resulting solid was dried under vacuum at 50° C. to give the title compound.

Provenance & Evidence