Acetic Anhydride → 1-(2-Methyl-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one

Participants

Reaction Steps

2-Methyl-1,2,3,4-tetrahydroquinoline (216 mg, 1.469 mmol, available from TCl), was measured into a reaction test tube and acetic anhydride (0.139 ml, 1.469 mmol) was added and left to stir overnight. LCMS analysis showed the reaction had gone to completion. The crude product was purified by MDAP to give the desired compound (677 mg)

Provenance & Evidence