HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2201353Generated: October 29, 2026
1-Hydroxybenzotriazole → HCID 118148696, compound
https://huagongshe.com/reaction/2201353
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | N2-Methyl-5-(trifluoromethyl)pyridine-2,3-diamine | HCID 2735930 | — |
| Reactant | HCID 117988971 | HCID 117988971 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 118148696 | HCID 118148696 | 966.3% |
Reaction Steps
A mixture of 618 mg of N2-methyl-5-trifluoromethylpyridine-2,3-diamine, 612 mg of 3-ethylsulfanylpyridazine-2-carboxylic acid, 958 mg of EDCI hydrochloride, 45 mg of HOBt and 5 ml of pyridine was stirred at 60° C. for 4 hours. Water was poured to the cooled reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, and then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 1.15 g of 3-ethylsulfanylpyrazine-2-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide. 3-Ethylsulfanylpyrazine-2-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09364000B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-0e3e398ff6b04da2914e8f913d7e9600 |
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| Source note | uspto-grants-2016_06 |
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