Dimethylformamide → HCID 117988910, compound

Participants

Reaction Steps

2.77 g of ethyl mercaptan sodium salt (80%) was added to a mixture of 4.69 g of 4-chloropyrimidine-5-carboxylic acid ethyl ester, 8 ml of DMF and 7 ml of THF was added under ice cooling, then the mixture was heated to room temperature, and stirred for 1 hour. Water was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 2.41 g of 4-ethylsulfanylpyrimidine-5-carboxylic acid ethyl ester. 4-Ethylsulfanylpyrimidine-5-carboxylic acid ethyl ester

Provenance & Evidence