Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | N2-Methyl-5-(trifluoromethyl)pyridine-2,3-diamine | HCID 2735930 | — |
| Reactant | 4-Ethylsulfanylpyrimidine-5-carboxylic acid | HCID 117988923 | — |
| Catalyst | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 118148713 | HCID 118148713 | 100% |
Reaction Steps
A mixture of 1.04 g of N2-methyl-5-trifluoromethylpyridine-2,3-diamine, 1.00 g of 4-ethylsulfanylpyrimidine-5-carboxylic acid, 1.57 g of EDCI hydrochloride, 73 mg of HOBt and 5 ml of pyridine was stirred at 60° C. for 4 hours. Water was poured to the cooled reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 1.94 g of 4-ethylsulfanylpyrimidine-5-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide. 4-Ethylsulfanylpyrimidine-5-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09364000B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-8d5183925ffd47aa93890955e8b5d4e1 |
|---|
| Source note | uspto-grants-2016_06 |
|---|
