Sodium Thiosulfate → HCID 117989538, compound

Participants

Reaction Steps

189 mg of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to a mixture of 130 mg of 2-(4-ethylsulfanylpyrimidin-5-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine and 4 ml of chloroform, then the mixture was stirred at room temperature for 8 hours. A 10% aqueous sodium thiosulfate solution was poured to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain 130 mg of 2-(4-ethylsulfonylpyrimidin-5-yl)-3-methyl-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine (hereinafter, referred to as Compound of Present Invention 15).

Provenance & Evidence