Dimethylformamide → HCID 118148716, compound

Participants

Reaction Steps

6 ml of a DMF solution of 342 mg of ethyl mercaptan sodium salt (80%) was added to a mixture of 1.19 g of 3,6-dichloropyridazine-4-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide, 2 ml of DMF and 2 ml of THF under ice cooling, then the mixture was heated to room temperature, and stirred for 1 hour. The mixture was allowed to stand overnight, then water was poured to the reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.04 g of 6-chloro-3-ethylsulfanylpyridazine-4-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide. 6-chloro-3-ethylsulfanylpyridazine-4-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide

Provenance & Evidence