反应详情

温度

50 °C

A mixture of 0.69 g of 2-ethylsulfanyl-N-(2-hydroxy-5-trifluoromethylpyridin-3-yl) nicotinamide, 0.75 g of bis(2-methoxyethyl) azodicarboxylate (hereinafter referred to as DMEAD), 0.79 g of triphenylphosphine and 7 ml of THF was stirred at 50° C. for 4 hours. A saturated aqueous ammonium chloride solution was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over sodium sulfate, and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.34 g of 2-(2-ethylsulfanylpyridin-3-yl)-6-(trifluoromethyl)oxazolo[5,4-b]pyridine (hereinafter, referred to as Compound of Present Invention 32).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under reduced pressure