Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Hydroxybenzotriazole → HCID 178477293, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 4-Ethylsulfanylnicotinic acid hydrochloride | HCID 117988707 | — |
| 반응물 | HCID 178507667 | HCID 178507667 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | HCID 178477293 | HCID 178477293 | 59.3% |
반응 단계
A mixture of 450 mg of 3-amino-5-trifluoromethylpyridine-2-thiol, 637 mg of 4-ethylsulfanylnicotinic acid hydrochloride, 532 mg of EDCI hydrochloride, 31 mg of HOBt and 5 ml of pyridine was stirred at room temperature for 2 hours and then stirred at 60° C. for 30 minutes. Water was poured to the reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 494 mg of 4-ethylsulfanyl-N-[2-mercapto-5-(trifluoromethyl)pyridin-3-yl]nicotinamide. 4-ethylsulfanyl-N-[2-mercapto-5-(trifluoromethyl)pyridin-3-yl]nicotinamide
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09364000B2 |
| 출처 데이터셋 | uspto-grants-2016_06 |
| ORD ID | ord-40aafddc2db44988857d67f62799199e |
| 출처 메모 | uspto-grants-2016_06 |