Dimethylformamide → 2-(4-Ethylsulfanylpyridin-3-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine

Participants

Reaction Conditions

Reaction Steps

A mixture of 494 mg of 4-ethylsulfanyl-N-[2-mercapto-5-(trifluoromethyl)pyridin-3-yl]nicotinamide, 1.05 g of p-toluenesolufonic acid-hydrate, 3 ml of DMF and 1 ml of toluene was heated and stirred at 150° C. for 10 hours. A saturated aqueous sodium bicarbonate solution was poured to the cooled reaction mixture, and the precipitated solid was filtered. The resulting solid was applied to a silica gel column chromatography to obtain 146 mg of 2-(4-ethylsulfanylpyridin-3-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine (hereinafter, referred to as Compound of Present Invention 42).

Provenance & Evidence