Sodium Thiosulfate → 2-(4-Ethylsulfonylpyridin-3-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine

Participants

Reaction Steps

217 mg of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to a mixture of 146 mg of 2-(4-ethylsulfanylpyridin-3-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine and 5 ml of chloroform under ice cooling, then the mixture was stirred at room temperature for 8 hours. An aqueous sodium thiosulfate solution was poured to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous sodium sulfate, then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 81 mg of 2-(4-ethylsulfonylpyridin-3-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine (hereinafter, referred to as Compound of Present Invention 43) and 29 mg of 2-(4-ethylsulfonyl-1-oxypyridin-3-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine (hereinafter, referred to as Compound of Present Invention 44).

Provenance & Evidence