Sodium Thiosulfate → HCID 117988715, compound

Participants

Reaction Steps

265 mg of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to a mixture of 0.38 g of 2-(2-ethylsulfanylpyridin-3-yl)-5-(trifluoromethyl)benzothiazole and 4 ml of chloroform under ice cooling, then the mixture was stirred for 30 minutes under ice cooling. 265 mg of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to the reaction mixture under ice cooling, then the mixture was stirred at room temperature for 1 hour. An aqueous sodium thiosulfate solution was poured to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.35 g of 2-(2-ethylsulfonylpyridin-3-yl)-5-(trifluoromethyl)benzothiazole (hereinafter, referred to as Compound of Present Invention 46).

Provenance & Evidence