Hydrochloric Acid → HCID 17926257, compound

Participants

Reaction Steps

To a solution of 7.60 g (0.045 mol) 5-nitroso-2,4-diamino-6-methoxypyrimidine from step 1.2 in 400 ml ethanol was added 1.5 g (0.04 mol %) palladium on charcoal (5%). The mixture was shaken at room temperature for 16 h under an atmosphere of hydrogen at 1 bar. The reaction mixture was then poured into 80 ml dilute hydrochloric acid (0.23 mol), the catalyst was filtered off and the filtrate was concentrated almost to dryness. The precipitated crystals were filtered off with suction and washed with tert-butyl methyl ether. 6-Methoxy-2,4,5-pyrimidinetriamine dihydrochloride (8.10 g, 79%) was obtained as light yellow crystals.

Provenance & Evidence