Acetic Acid → HCID 117871909, compound

Participants

Reaction Steps

To a stirred solution of 51.0 g (0.26 mol) 6-(3-methylbutoxy)-2,4-diaminopyrimidine in 520 ml acetic acid (10% conc. in water) at 55-60° C. was added dropwise over a period of 25 min a solution of 23.5 g (0.34 mol) sodium nitrite in 105 ml water. Stirring was then continued for a further 1 h at 50-55° C. and overnight at room temperature. The resulting precipitate was filtered off with suction, washed with water and dried. The crude product was recrystallized from a 1:1 mixture of water/ethanol to yield 5-nitroso-2,4-diamino-6-(2-methylbutoxy)pyrimidine (19.0 g, 32%) as a violet solid.

Provenance & Evidence