Ethylene Glycol → HCID 22639954, compound

Participants

Reaction Conditions

Reaction Steps

28.9 g (0.20 mol) of 2,4-diamino-6-chloropyrimidine was added to a solution of 4.6 g (0.20 mol) of sodium in 124 ml of ethylene glycol and heated to 80° C. for 44 h while stirring was performed. After termination of the reaction, the solution was diluted with 300 ml of water and extracted with tert-butyl methyl ether (5×200 ml). The combined organic phases were discarded; a precipitate precipitated out of the aqueous phases. The precipitate was washed with water; after drying, 2-[(2,6-diaminopyrimidin-4-yl)oxy]ethan-1-ol (16.1 g, 47%) was obtained as a light-beige solid.

Provenance & Evidence