Hydrochloric Acid → HCID 131735716, compound

Participants

Reaction Steps

1.5 g (0.04 mol %) of palladium on carbon (5%) was added to a solution of 6.57 g (0.033 mol) of 2-[(2,6-diamino-5-nitrosopyrimidin-4-yl)oxy]ethan-1-ol from step 4.2 in 400 ml of ethanol, and shaking was performed at room temperature for 19 h under hydrogen-1 atmosphere. Then the reaction mixture was poured into 150 ml of diluted hydrochloric acid (0.30 mol), the catalyst was filtered off, and the filtrate was concentrated almost to dryness. The precipitated crystals were sucked off and post-washed with tert-butyl methyl ether. 2-[(2,5,6-triaminopyrimidin-4-yl)oxy]ethanol, dihydrochloride (7.17 g, 84%) was obtained as light-yellow crystals.

Provenance & Evidence